The sum of the series $2 \times 1 \times{ }^{20} \mathrm{C}_4-3 \times 2 \times{ }^{20} \mathrm{C}_5+4 \times 3 \times{ }^{20} \mathrm{C}_6-5 \times 4 \times{ }^{20} \mathrm{C}_7+\cdots \cdots+18 \times 17 \times{ }^{20} \mathrm{C}_{20}$, is equal to ____________.

If the function $f(x)=\frac{\tan (\tan x)-\sin (\sin x)}{\tan x-\sin x}$ is continuous at $x=0$, then $f(0)$ is equal to ____________.

If $\int\left(\frac{1}{x}+\frac{1}{x^3}\right)\left(\sqrt[23]{3 x^{-24}+x^{-26}}\right) \mathrm{d} x=-\frac{\alpha}{3(\alpha+1)}\left(3 x^\beta+x^\gamma\right)^{\frac{\alpha+1}{\alpha}}+C, x>0,(\alpha, \beta, \gamma \in \mathbf{Z})$, where C is the constant of integration, then $\alpha+\beta+\gamma$ is equal to ___________.

Let the lengths of the transverse and conjugate axes of a hyperbola in standard form be $2 a$ and $2 b$, respectively, and one focus and the corresponding directrix of this hyperbola be $(-5,0)$ and $5 x+9=0$, respectively. If the product of the focal distances of a point $(\alpha, 2 \sqrt{5})$ on the hyperbola is $p$, then $4 p$ is equal to ___________.