The relative reactivities of acyl compounds towards nucleophilic substitution are in the order of
A
Acid anhydride > Amide > Ester > Acyl chloride
B
Acyl chloride > Ester > Acid anhydride > Amide
C
Acyl chloride > Acid anhydride > Ester > Amide
D
Ester > Acyl chloride > Amide > Acid anhydride.
Explanation
The more the basic character of the leaving
group, the lesser is the reactivity the basic
character follows the order
NH2– > OR– > RCOO– > Cl–
Hence, the relative reactivities of acyl
compounds towards nucleophilic substitution
follow the order
Acyl halides > Acid anhydride
> Ester > Amide.