Choose the correct statement(s) with respect to Down's syndrome
i. Down's syndrome results from non-disjunction of $21^{\text {st }}$ chromosome during gamete formation.
ii. Down's syndrome is a sex chromosomal disorder observed in immature mothers who are below the age of 18 .
iii. These patients have mild mental retardation, poor skeletal development, flat hands, stubby fingers and palms are broader.
iv. The have 44 A with XO type of karyotype.
v. The risk of giving birth to a Down Syndrome child is more in mothers who are over 45 years of age.
| Column - I | Column - II | ||
|---|---|---|---|
| i. | Thalassemia | a. | X monosomy |
| ii. | Turner's syndrome | b. | Extra X chromosomes in male |
| iii | Klinefelter's syndrome | c. | $$ 21^{\text {st }} \text { Trisomy } $$ |
| iv. | Down's syndrome | d. | Mendelian disorder |
Which one of the following is an EXCEPTION to the generalization made by Mendel on the basis of his experiments on garden pea plant?
Given below are two statements:
Statement I - Back cross is the crossing of $F_1$ hybrid with one of the two parents from which they were derived.
Statement II - Test cross involves the crossing of $F_1$ - hybrid with its homozygous recessive parent.
In light of above statements, choose the correct answer from the option given below.
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